The Oscar-nominated Mank actress has been tapped to replace Kate McKinnon and star as Elizabeth Holmes in Hulu’s highly anticipated limited series The Dropout.

Based on the ABC News podcast, the limited series traces how Theranos founder Holmes raised hundreds of millions to fund the biotech startup and became a media darling while hiding the fact that her touted blood-testing machine didn’t really work. The drama is based on an ABC News podcast of the same name, which also was the basis for a 20/20 episode.

Showrunner Elizabeth Meriwether (New Girl), Liz Heldens (The Passage), Liz Hannah, Katherine Pope, podcast host/ABC News’ Rebecca Jarvis, Victoria Thompson and Taylor Dunn exec produce. The series is from Searchlight’s TV division and 20th Television. Seyfried will also be credited as a producer on The Dropout.